diff --git a/Detectors/Upgrades/ALICE3/IOTOF/simulation/include/IOTOFSimulation/DPLDigitizerParam.h b/Detectors/Upgrades/ALICE3/IOTOF/simulation/include/IOTOFSimulation/DPLDigitizerParam.h
index 48c873d86dc2f..6e6ecb3ec53e2 100644
--- a/Detectors/Upgrades/ALICE3/IOTOF/simulation/include/IOTOFSimulation/DPLDigitizerParam.h
+++ b/Detectors/Upgrades/ALICE3/IOTOF/simulation/include/IOTOFSimulation/DPLDigitizerParam.h
@@ -31,15 +31,6 @@ struct DPLDigitizerParam : public o2::conf::ConfigurableParamHelper<DPLDigitizer
   float tdcBin = 0.010f;         ///< TDC time bin (10 ps default)
   float efficiency = 0.98f;      ///< detection efficiency
 
-  // Optional map paths. Prefix with "ccdb://" to fetch from CCDB, otherwise the path is opened with TFile::Open
-  // (local file, alien://, root://, ...). An empty path disables the map.
-  std::string efficiencyMapPath{};    ///< optional efficiency map path.
-                                      ///< e.g. ccdb://Users/g/glucia/tmp/ALICE3/IOTOF/pixelEfficiency
-                                      ///< or alien:///alice/cern.ch/user/g/glucia/ALICE3/IOTOF/pixelEfficiency/PixelEfficiencyMap_TH2.root
-  std::string resolutionMapPath{};    ///< optional resolution map path.
-                                      ///< e.g. alien:///alice/cern.ch/user/g/glucia/ALICE3/IOTOF/pixelEfficiency/PixelResolutionMap_TH2.root
-  std::string timeOfArrivalMapPath{}; ///< optional time of arrival map path.
-
   int chargeThreshold = 100;              ///< charge threshold in Nelectrons
   int minChargeToAccount = 7;             ///< minimum charge contribution to account
   int nSimSteps = 10;                     ///< number of steps in response simulation
diff --git a/Detectors/Upgrades/ALICE3/IOTOF/simulation/include/IOTOFSimulation/Digitizer.h b/Detectors/Upgrades/ALICE3/IOTOF/simulation/include/IOTOFSimulation/Digitizer.h
index 2b2a549b37d59..4ed2f87ba5aeb 100644
--- a/Detectors/Upgrades/ALICE3/IOTOF/simulation/include/IOTOFSimulation/Digitizer.h
+++ b/Detectors/Upgrades/ALICE3/IOTOF/simulation/include/IOTOFSimulation/Digitizer.h
@@ -75,6 +75,12 @@ class Digitizer : public TObject
   // Provide the common iotof::GeometryTGeo to access matrices and segmentation
   void setGeometry(const o2::iotof::GeometryTGeo* gm) { mGeometry = gm; }
 
+  void loadEfficiencyMap(TH2D* map) { mEfficiencyMap = map; }
+  void loadResolutionMap(TH2D* map) { mResolutionMap = map; }
+  void loadTimeOfArrivalMap(TH2D* map) { mTimeOfArrivalMap = map; }
+
+  void prepareScaledResolutionMap();
+
  private:
   /// Process a single hit
   void processHit(const o2::itsmft::Hit& hit, int evID, int srcID);
@@ -91,12 +97,6 @@ class Digitizer : public TObject
   /// Convert energy loss to charge
   int energyToCharge(float energyLoss) const;
 
-  /// Load a map from CCDB (path prefixed with "ccdb://") or from a ROOT file (any other path)
-  /// \param mapName Name of the histogram inside the ROOT file (ignored for CCDB)
-  void loadMap(TH2D*& map, const std::string& path, const char* mapName);
-
-  void prepareScaledResolutionMap();
-
   /// Check if the hit passes efficiency cut
   /// \param x Detector local coordinate x in cm with respect to the center of the sensitive volume.
   /// \param z Detector local coordinate z in cm with respect to the center of the sensitive volume.
diff --git a/Detectors/Upgrades/ALICE3/IOTOF/simulation/src/Digitizer.cxx b/Detectors/Upgrades/ALICE3/IOTOF/simulation/src/Digitizer.cxx
index a7adbb9b2485d..2e8bd96b6b8e3 100644
--- a/Detectors/Upgrades/ALICE3/IOTOF/simulation/src/Digitizer.cxx
+++ b/Detectors/Upgrades/ALICE3/IOTOF/simulation/src/Digitizer.cxx
@@ -73,22 +73,6 @@ void Digitizer::init()
   LOG(info) << "  Charge threshold: " << digitizerParams.chargeThreshold << " electrons";
   LOG(info) << "  Continuous mode: " << (mContinuous ? "ON" : "OFF");
 
-  loadMap(mEfficiencyMap, digitizerParams.efficiencyMapPath, "hEfficiencyMap");
-  if (!mEfficiencyMap) {
-    LOG(info) << "No efficiency map loaded, using uniform efficiency: " << digitizerParams.efficiency * 100 << " %";
-  }
-
-  loadMap(mResolutionMap, digitizerParams.resolutionMapPath, "hSigmaPixel");
-  prepareScaledResolutionMap();
-  if (!mResolutionMap) {
-    LOG(info) << "No resolution map loaded, using uniform time resolution: " << digitizerParams.timeResolution * 1e3 << " ps";
-  }
-
-  loadMap(mTimeOfArrivalMap, digitizerParams.timeOfArrivalMapPath, "toa_pixel");
-  if (!mTimeOfArrivalMap) {
-    LOG(info) << "No time of arrival map loaded";
-  }
-
   sSegmentation = o2::iotof::Segmentation::Instance();
 }
 
@@ -374,61 +358,6 @@ int Digitizer::energyToCharge(float energyLoss) const
 }
 
 //_______________________________________________________________________
-
-void Digitizer::loadMap(TH2D*& map, const std::string& path, const char* mapName)
-{
-  // Load a map either from CCDB (path prefixed with "ccdb://") or from a ROOT file
-  // (anything TFile::Open understands: local path, alien://, root://, http://, ...)
-  static constexpr std::string_view ccdbPrefix = "ccdb://";
-
-  if (path.empty()) {
-    return;
-  }
-
-  TH2D* rawMap = nullptr;
-  TFile* file = nullptr;
-
-  if (path.rfind(ccdbPrefix, 0) == 0) {
-    const std::string ccdbPath = path.substr(ccdbPrefix.size());
-    LOG(info) << "Loading " << mapName << " from CCDB: " << ccdbPath;
-    rawMap = o2::ccdb::BasicCCDBManager::instance().get<TH2D>(ccdbPath); // owned by the CCDB manager
-    if (!rawMap) {
-      LOG(error) << "Failed to retrieve " << mapName << " from CCDB path: " << ccdbPath;
-      return;
-    }
-  } else {
-    LOG(info) << "Loading " << mapName << " from file: " << path;
-    file = TFile::Open(path.c_str());
-    if (!file || !file->IsOpen()) {
-      LOG(error) << "Failed to open file: " << path;
-      delete file;
-      return;
-    }
-    rawMap = dynamic_cast<TH2D*>(file->Get(mapName));
-    if (!rawMap) {
-      LOG(error) << "Failed to retrieve " << mapName << " from file: " << path;
-      LOG(error) << "Available keys in the file:";
-      TIter next(file->GetListOfKeys());
-      TKey* key;
-      while ((key = dynamic_cast<TKey*>(next()))) {
-        LOG(error) << "  " << key->GetName() << " (" << key->GetClassName() << ")";
-      }
-      file->Close();
-      delete file;
-      return;
-    }
-  }
-
-  map = dynamic_cast<TH2D*>(rawMap->Clone());
-  map->SetDirectory(nullptr); // Detach from file to avoid deletion when file is closed
-  LOG(info) << "Loaded " << mapName << " (" << map->GetNbinsX() << " x " << map->GetNbinsY() << " bins)";
-
-  if (file) {
-    file->Close();
-    delete file;
-  }
-}
-
 void Digitizer::prepareScaledResolutionMap()
 {
   if (!mResolutionMap) {
diff --git a/Steer/DigitizerWorkflow/src/IOTOFDigitizerSpec.cxx b/Steer/DigitizerWorkflow/src/IOTOFDigitizerSpec.cxx
index 1fa43b72684a3..6c0bfc2b0760d 100644
--- a/Steer/DigitizerWorkflow/src/IOTOFDigitizerSpec.cxx
+++ b/Steer/DigitizerWorkflow/src/IOTOFDigitizerSpec.cxx
@@ -54,6 +54,10 @@ class IOTOFDPLDigitizerTask : o2::base::BaseDPLDigitizer
   void initDigitizerTask(framework::InitContext& ic) override
   {
     mDisableQED = ic.options().get<bool>("disable-qed");
+    mEnableResponseFiles = ic.options().get<bool>("enable-response-files");
+    mLocalEfficiencyFile = ic.options().get<std::string>("local-efficiency-file");
+    mLocalTimeResoFile = ic.options().get<std::string>("local-timereso-file");
+    mLocalToAFile = ic.options().get<std::string>("local-toa-file");
 
     auto geom = GeometryTGeo::Instance();
     geom->fillMatrixCache(o2::math_utils::bit2Mask(o2::math_utils::TransformType::L2G)); // make sure L2G matrices are loaded
@@ -69,6 +73,13 @@ class IOTOFDPLDigitizerTask : o2::base::BaseDPLDigitizer
     if (mFinished) {
       return;
     }
+
+    if (mEnableResponseFiles) {
+      pc.inputs().get<TH2D*>("madpixeff");
+      pc.inputs().get<TH2D*>("madpixreso");
+      pc.inputs().get<TH2D*>("madpixtoa");
+    }
+
     mFirstOrbitTF = pc.services().get<o2::framework::TimingInfo>().firstTForbit;
     const o2::InteractionRecord firstIR(0, mFirstOrbitTF);
 
@@ -163,10 +174,59 @@ class IOTOFDPLDigitizerTask : o2::base::BaseDPLDigitizer
     mFinished = true;
   }
 
+  void finaliseCCDB(ConcreteDataMatcher& matcher, void* obj)
+  {
+    if (matcher == ConcreteDataMatcher(mOrigin, "MADPIXEFF", 0)) {
+      if (mLocalEfficiencyFile.empty()) {
+        LOG(info) << "Using CCDB/MADPIX efficiency file";
+        mDigitizer.loadEfficiencyMap((TH2D*)obj);
+      } else {
+        LOG(info) << "Response function will be loaded from local file: " << mLocalEfficiencyFile;
+        std::unique_ptr<TFile> file(TFile::Open(mLocalEfficiencyFile.data(), "READ"));
+        if (!file) {
+          LOG(fatal) << "Cannot open response file " << mLocalEfficiencyFile.data();
+        }
+        mDigitizer.loadEfficiencyMap((TH2D*)file->Get("efficiency_pixel"));
+      }
+      return;
+    }
+    if (matcher == ConcreteDataMatcher(mOrigin, "MADPIXRESO", 0)) {
+      if (mLocalTimeResoFile.empty()) {
+        LOG(info) << "Using CCDB/MADPIX time resolution file";
+        mDigitizer.loadResolutionMap((TH2D*)obj);
+      } else {
+        LOG(info) << "Response function will be loaded from local file: " << mLocalTimeResoFile;
+        std::unique_ptr<TFile> file(TFile::Open(mLocalTimeResoFile.data(), "READ"));
+        if (!file) {
+          LOG(fatal) << "Cannot open response file " << mLocalTimeResoFile.data();
+        }
+        mDigitizer.loadResolutionMap((TH2D*)file->Get("sigma_pixel"));
+      }
+      return;
+    }
+    if (matcher == ConcreteDataMatcher(mOrigin, "MADPIXTOA", 0)) {
+      if (mLocalToAFile.empty()) {
+        LOG(info) << "Using CCDB/MADPIX time-of-arrival file";
+        mDigitizer.loadTimeOfArrivalMap((TH2D*)obj);
+      } else {
+        LOG(info) << "Response function will be loaded from local file: " << mLocalToAFile;
+        std::unique_ptr<TFile> file(TFile::Open(mLocalToAFile.data(), "READ"));
+        if (!file) {
+          LOG(fatal) << "Cannot open response file " << mLocalToAFile.data();
+        }
+        mDigitizer.loadTimeOfArrivalMap((TH2D*)file->Get("toa_pixel"));
+      }
+    }
+  }
+
  private:
   bool mDisableQED = false;
+  bool mEnableResponseFiles = false;
   bool mWithMCTruth{true};
   bool mFinished{false};
+  std::string mLocalEfficiencyFile{""};
+  std::string mLocalTimeResoFile{""};
+  std::string mLocalToAFile{""};
   unsigned long mFirstOrbitTF = 0x0;
   const o2::detectors::DetID mID{o2::detectors::DetID::TF3};
   const o2::header::DataOrigin mOrigin{o2::header::gDataOriginTF3};
@@ -197,7 +257,9 @@ o2::framework::DataProcessorSpec getIOTOFDigitizerSpec(int channel, bool mctruth
 {
   std::vector<o2::framework::InputSpec> inputs;
   inputs.emplace_back("collisioncontext", "SIM", "COLLISIONCONTEXT", static_cast<o2::header::DataHeader::SubSpecificationType>(channel), o2::framework::Lifetime::Timeframe);
-  inputs.emplace_back("IOTOF_aptsresp", "TF3", "APTSRESP", 0, o2::framework::Lifetime::Condition, o2::framework::ccdbParamSpec("IT3/Calib/APTSResponse"));
+  inputs.emplace_back("madpixeff", "TF3", "MADPIXEFF", 0, o2::framework::Lifetime::Condition, o2::framework::ccdbParamSpec("Users/g/glucia/tmp/ALICE3/IOTOF/pixelEfficiency"));
+  inputs.emplace_back("madpixreso", "TF3", "MADPIXRESO", 0, o2::framework::Lifetime::Condition, o2::framework::ccdbParamSpec("Users/g/glucia/tmp/ALICE3/IOTOF/pixelResolution"));
+  inputs.emplace_back("madpixtoa", "TF3", "MADPIXTOA", 0, o2::framework::Lifetime::Condition, o2::framework::ccdbParamSpec("Users/g/glucia/tmp/ALICE3/IOTOF/pixelTimeOfArrival"));
 
   const std::string detStr = o2::detectors::DetID::getName(o2::detectors::DetID::TF3);
   return o2::framework::DataProcessorSpec{detStr + "Digitizer",
@@ -206,7 +268,10 @@ o2::framework::DataProcessorSpec getIOTOFDigitizerSpec(int channel, bool mctruth
                                           o2::framework::AlgorithmSpec{o2::framework::adaptFromTask<IOTOFDPLDigitizerTask>(mctruth)},
                                           o2::framework::Options{
                                             {"disable-qed", o2::framework::VariantType::Bool, false, {"disable QED handling"}},
-                                            {"local-response-file", o2::framework::VariantType::String, "", {"use response file saved locally at this path/filename"}}}};
+                                            {"enable-response-files", o2::framework::VariantType::Bool, false, {"enable in-pixel response maps from data"}},
+                                            {"local-efficiency-file", o2::framework::VariantType::String, "", {"use efficiency map saved locally at this path/filename"}},
+                                            {"local-timereso-file", o2::framework::VariantType::String, "", {"use time resolution map saved locally at this path/filename"}},
+                                            {"local-toa-file", o2::framework::VariantType::String, "", {"use ToA map saved locally at this path/filename"}}}};
 }
 
 } // namespace o2::iotof